Endogenous Reporter Cells
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Endogenous Reporter Cells
Endogenous
reporter cells are the most comprehensive means of indexing gene
expression. Xactagen produces endogenous reporter cells by
introducing promoterless and enhancerless vectors containing
membrane-anchored Gaussia luciferase, secreted
Gaussia luciferase, or Ptilosarcus GFP into natural
genes. As a result, gene regulation accurately reflects
activities of natural promoters, enhancers, silencers and
micro-RNAs as well as localized chromosomal influences such as DNA
methylation.
Proprietary
methods can now produce endogenous reporter cells for virtually any
receptor, gene, signaling pathway, or drug/drug candidate.
- Gene targeting: Produces
reporter cells for specific genes.
- Induction cloning: Large
libraries of endogenous reporter cells are produced using
Xactagen's proprietary gene trap vectors. From these,
reporter cells responsive to drug products, chemical agents, or
specific pathways are attained. Especially popular are drug
responsive reporter cells that monitor cellular delivery and target
efficacy, both in cell culture and in vivo using whole
animal imaging.
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Price |
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Gene Targeted Endogenous Reporter Cell Production |
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$9,450.00
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Induction Cloned Endogenous Reporter Cells |
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Inquire
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